Topically applied remedies provide release of drugs directly at the pathological site and provide a number of advantages over conventional methods of drug administration. Miconazole Nitrate has good antifungal activity. The aim of study was to design and evaluation of miconazole nitrate microsponge for sustained release topical drug delivery system by quasi-emulsion diffusion method. The average size of microsponge formulation is less than 300�µm. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability and solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, Polyvinyl alcohol as an emulsifying agent, Triethyl citrate as a plasticizer, Dichloro methane and methanol used as solvent. \r\nFor the optimization of Miconazole Nitrate loaded microsponge Central Composite Design was employed. Process variable like Speed (X1), PVA concentration (X2), Drug: Polymer Ratio (X3) was defined as factors, where as Loading Efficiency (Y1), Production Yield (Y2), Drug Content (Y3) and Particle Size (Y4) and Cumulative percentage release (Y5). The optimized batch of Miconazole Nitrate loaded microsponge was evaluated by Particles size, shape and internal structure by SEM. Compatibility was evaluated by FTIR of optimized batch. In vitro dissolution study of miconazole nitrate microsponge confirmed that it gives sustained release effect up to 12 hour. Kinetic models of formulation confirmed that, it follows zero order kinetic. The optimized batch of microsponge was incorporated in to carbopol 934 gel, and it showed desired drug content, in vitro diffusion, spreadability, pH and viscosity as per standard criteria.
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